Ingredient Details

Our Ingredient Principles

At Perelel, we do the heavy lifting for you. That's why we select only high-quality, doctor-recommended ingredients that meet the highest standards for safety, efficacy, and transparency.

Our medical co-founder, Dr. Banafsheh Bayati—OB/GYN, MD, FACOG—works with an exclusive team of world-class doctors and leading experts to ensure every formula reflects real patient needs.

See how our ingredient principles come to life.

Our formulas use research-backed doses, guided by our medical co-founder and OB/GYN panel, to ensure every ingredient makes an impact.

Based on decades of research and patient insights.

Choline

Most women, including 95% of U.S. pregnant women, do not consume enough choline daily. We use the clinically validated dose of choline to support infant brain development. Choline is also important for all life stages - continuing to support liver health and cellular metabolism throughout a woman's life.**

Clinical Research:

Zeisel et al. Annu Rev Nutr. 2008
Derbyshire et al. Nutrients. 2020
Klatt et al. Am J Clin Nutr. 2022
Caudill et al. FASEB J. 2018

Source:

VitaCholine® in our Choline Boost and Core Prenatal Multivitamin.

Vitamin D3

On average, only 37% of pregnant women in the US consume the recommended daily amount of vitamin D and many women have insufficient levels of Vitamin D (even in sunny climates!) That’s why our medical Panel formulated our multivitamins with 2000 IU (50 mcg) of Vitamin D3—so we could be confident that this dosage would help maintain blood levels.*

Clinical Research:

Bailey et al., JAMA Netw Open. 2019
Bodner et al., J Nutr. 2007
Palacios et al. J Steroid Biochem Mol Biol. 2016
Mithal et al. Indian J Endocrinol Metab. 2014
Holick et al. J Clin Endocrinol Metab. 2011

Source:

50 mcg (2000 IU) Cholecalciferol in our Core Prenatal Multivitamin, Women’s Multivitamin, Men’s Multivitamin, and 100 mcg (400 IU) in our Perimenopause Multivitamin

Bacillus subtilis DE111®

Bacillus subtilis DE111® is a probiotic strain that has been clinically studied to support overall immune and gastrointestinal health. This patented spore-based probiotic helps promote bowel regularity in adults and has been proven to survive in the human GI tract.*

Clinical Research:

Freedman et al. Int J Mol Sci. 2021
Colom et al. Front Microbiol. 2021
Cuentas et al. J Prob Health. 2017

Source:

Bacillus subtilis (DE111) in our Synbiotic Greens Powder

Inositol Blend

In our Hormonal Balance Support capsules, we include both Myo-Inositol and D-Chiro-Inositol at the clinically studied ratio for supporting healthy ovulation (40:1)—according to research and clinical insights from our Perelel Panel. Myo-inositol has been studied in over 40 human clinical trials.*

Clinical Research:

Nordio et al. Euro Review for Med & Pharm Sci. 2019
Lei et al. Medicine. 2020
Fitz et al. J Clin Endocrinol Metab. 2024

Source:

1,000 mg Myo-inositol and 25 mg D-chiro-inositol in our Hormonal Balance Support

Sensoril® Ashwagandha

We opt for a clinically studied form of Ashwagandha, Sensoril®, that has been clinically shown to support stress, energy, mood, and healthy cortisol levels*.*

Clinical Research:

Salve et al. Cureus. 2019
Auddy et al. J of American Nutraceutical Assoc. 2008

Source:

150 mg Ashwagandha Stem and Leaf Extract (Sensoril®) in our Perimenopause Support Pack and Stress Support

We select high-quality ingredients in absorbable, bioavailable formats.

Did you know: all of our minerals are chelated for optimal absorption.*

Methylfolate

Methylfolate is the active form of folate in the body, so it is ready for your body to use—compared to the synthetic form, folic acid, which needs to be converted to methylfolate. Emerging clinical evidence consistently demonstrates that methylated folate is at least as effective as folic acid for improving biomarkers of folate status — with additional advantages in safety and inclusivity for women with impaired folic acid metabolism.* In fact, in our 12 week clinical trial, women taking our Conception Support Pack had a 228% increase in folate levels and 96% of women had serum folate levels in the recommended range.‡

Clinical Research:

Lamers et al. The American J of Clinical Nutr. 2006
Gaskins et al. PLOS One. 2013
Tsang et al., Am J of Clin Nutr., 2015
Moll et al., Circulation, 2015

Source:

L-5 methyltetrahydrofolate calcium in our Core Prenatal Multivitamin, Women’s Multivitamin, Men’s Multivitamin, Perimenopause Multivitamin, and CoQ10 and Folate

Iron

We use a patented, chelated form of iron that promotes optimal absorption. This form is gentle on the GI tract compared to traditional iron, which are known to cause digestive upset. There are more than 7 human clinical trials demonstrating iron chelate’s bioavailability and tolerability.* In our own clinical trial, our Conception Support Pack was shown to increase iron stores and support healthy iron status with 95% of women having healthy serum iron levels by the end of 12 weeks.

Clinical Research:

Milman et al. J Perinat Med. 2014
Mann et al. Food & Nutrition Bulletin. 2002
Fischer et al., Nutr Review. 2023

Source:

Iron bisglycinate chelate (FerrochelⓇ) in all of our Prenatal packs, Conception Support Pack, Mom Multi Pack, Egg Freeze Support, Iron Ease, and Recovery Support Pack

Magnesium

We chose a chelated source of magnesium for our prenatal that has been clinically demonstrated to be easier on the gastrointestinal tract than other sources. Magnesium Bisglycinate Chelate is a chelated format which means that it is bound to a chelated agent; meaning it has higher bioavailability and better absorption than other forms.

Clinical Research:

Tarjan et al. Adv Biomed Res. 2017
Schwalfenberg et al. Scientifica. 2017
Uberti et al. Nutrients. 2020

Source:

Magnesium Bisglycinate Chelate in our Prenatal Packs and Sleep Support Powder

We pair nutrients that work harder together for optimal absorption.

(Sometimes less isn't more.)

DHA + EPA

There are two main types of Omega-3s: long-chain omega-3s called EPA (eicosapentaenoic acid), known for it’s role in heart health, and DHA (docosahexaenoic acid), known for it’s role in brain health. Throughout pregnancy, EPA also plays a role in helping DHA cross the placenta, which is why we include both in our formulation. Our DHA and EPA are also certified by Friend of the Sea and MarinTrust, two of the leading organizations for sustainable and responsible fishery management.*

Clinical Research:

Greenberg et al. Rev Obstet Gynecol. 2008
Bauer et al. Human Psychopharmacology. 2014
Muldoon et al. Military Medicine. 2014
Greenberg et al.,Rev Obstet Gynecol. 2008
Kidd et al. Altern Med Rev. 2007
Antypa et al. J of Psychopharmacology. 2008

Source:

Friend of the Sea and Marine Trust-certified fish oil in our Omega softgels.

Vitamin C + Iron

Vitamin C has been shown to help facilitate iron absorption by capturing non-heme iron and storing it in a form that your body can absorb more easily. That is why all our products formulated with iron also have Vitamin C— to support optimal absorption of iron bisglycinate chelate.*

Clinical Research:

Khoshfetrat et al. Int J Prev Med. 2014
Lynch et al. Ann N Y Acad Sci. 1980
Biochemistry, Iron Absorption

Source:

Vitamin C (as ascorbic acid) and Iron (as iron bisglycinate chelate) in our Daily Iron Ease, Conception Support Pack, 1st Tri Support Pack, 2nd Tri Support Pack, 3rd Tri Support Pack, and Mom Multi Support Pack

Vitamin D3 + Vitamin K2

Our bodies need both Vitamin D and Vitamin K2—and when combined, they provide a synergistic effect for bone and heart health. Vitamin D helps your body absorb calcium and produce key proteins, but vitamin K2 activates them and ensures calcium goes to the right places—supporting your bones and promoting heart health. We formulated for all our multivitamins with both of these vitamins together to optimize your regimen.*

Clinical Research:

Van Ballegooijen et al. Int J Endocrinol. 2017
Kuang et al. Food Funct. 2020

Source:

Vitamin D3 (as cholecalciferol) + Vitamin K2 (as menaquinone-7) in all our Perelel Packs

DHA + Choline

DHA (or Docosahexaenoic acid, a type of Omega-3) and Choline play a synergistic role in brain and eye health. Both nutrients are critical for neurodevelopment and brain health. Choline supplementation has been shown to support levels of DHA both in infants and in pregnant women, which is why we have both sources of nutrients in our Perelel packs.*

Clinical Research:

Mun et al., Nutrients. 2019
Rajarethnem et al., Neurol Res Int. 2017
Bernhard et al., Eur J Nutr. 2020
Klatt et al., Am J Clin Nutr. 2022

Source:

DHA (Docosahexaenoic acid) + Choline Bitartrate in our Conception Support Pack, 1st Tri Support Pack, 2nd Tri Support Pack, 3rd Tri Support Pack, Mom Multi Support Pack, and Perimenopause Support Pack.

We formulate each product with nutrients to support your specific stage.

Because your needs aren't one-size-fits-all.

Folate

Folate is important for early neural, heart and face development, which starts before some women even know they are pregnant. That is why you will see additional folate in both our Conception Support and 1st Trimester Prenatal Packs.*

Clinical Research:

Gaskins et al. PLOS One. 2013
Lamers et al. The American J of Clinical Nutr. 2006
Brouwer et al. The American J of Clinical Nutrition. 1999

Source:

Conception Support Pack and 1st Trimester Prenatal Pack

CoQ10

We formulated our Conception Support, Men’s Multi Support, and Egg Freeze Support Packs with a CoQ10 capsule. CoQ10 is a dietary antioxidant that works to promote a healthy reproductive environment, which is necessary for egg and sperm health.**

Clinical Research:

Florou et al. J Assist Reprod Genet. 2020
Zhang et al. Human Reproduction Update. 2020
Casas et al., Nutrients, 2022.

Source:

Conception Support Pack, Men’s Multi Pack, and Egg Freeze Support Pack, Fertility + Capsules

Calcium + Magnesium

Skeletal growth for your baby increases in the second Trimester and continues throughout the third trimester, when maternal stores of these nutrients are passed to the baby. That is why we have additional Calcium + Magnesium support in both of those stages. Calcium is essential for fetal skeletal development while magnesium is supportive of muscle relaxation during a time of increased demand on the body’s stores.*

Clinical Research:

Bergel et al. BMC Pediatrics. 2007
Zarean Adv Biomed Res. 2017
Scientific Opinion on Dietary Reference Values for calcium
Supakatisant et al. Matern Child Nutr. 2015
Roffe et al. Med Sci Monit. 2002

Source:

2nd Trimester Prenatal Pack and 3rd Trimester Prenatal Pack

Lutein + Zeaxanthin

We use lutein and zeaxanthin, two carotenoids found in healthy foods but often underconsumed in the US diet. They are important for supporting cognitive health - critical for those in early motherhood - but also have been studied for infant brain and eye development for those who are breastfeeding.*

Clinical Research:

Sherry et al. J Nutr. 2014
Gazzalo et al. Nutrients. 2021
Addo et al. J Nutr. 2023
Lopresti et al. Front Nutr. 2022
Renzi-Hammond. Nutrients. 2017
Bovier at al. PLoS One. 2014
Yagi et al. Nutrients. 2021
Nouchi et al. Nutrients. 2020

Source:

Mom Multi Support Pack

Probiotics

Even microbiome support isn’t necessarily one-size-fits-all. We include a live strain probiotic blend in the 3rd Trimester Prenatal Pack with beneficial species of bacteria while our Synbiotic Greens Powder was formulated for all stages to provide 5 billion CFUs of a spore probiotic (DE111) that has been clinically studied to support digestive health.*

Clinical Research:

Edwards et al. MCN Am J Matern Child Nurs. 2018
Cuentas et al., 2017
Colom et al. Font Microbiol. 2021

Source:

3rd Trimester Prenatal Pack, Daily Probiotic, and Synbiotic Greens Powder

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
‡Based on a 12-week, randomized, double-blind, placebo-controlled clinical trial in 60 healthy women aged 21-40 with regular cycles and not using hormonal birth control. Recommended serum folate recommended for healthy conception and early fetal development is 15nmol/L.